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Search term: YOL081W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name IRA2
SGD link S000005441
Alternative ID YOL081W
Description GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
Synonyms YOL081W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1826 --DHY--

KOGs classification KOGs description
V
CELLULAR PROCESSES AND SIGNALING
Defense mechanisms
Ras GTPase activating protein RasGAP/neurofibromin

Species KOG link NCBI link UniProt link
Drosophila melanogaster (Dme) 7301417 GI:7301417 Q8IMS2
Homo sapiens (Hsa) Hs17477842 GI:17477842
Homo sapiens (Hsa) Hs22042396 GI:22042396
Homo sapiens (Hsa) Hs22055943 GI:22055943
Homo sapiens (Hsa) Hs22055996 GI:22055996
Homo sapiens (Hsa) Hs4505373
(NEK2)
GI:4505373 P51955
Homo sapiens (Hsa) Hs4557793
(NF1)
GI:4557793 P21359
Saccharomyces cerevisiae (Sce) YBR140c
(S000000344)
GI:6319616 P18963
Saccharomyces cerevisiae (Sce) YOL081w
(S000005441)
GI:6324491 P19158


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005441
TAS
HsaP21359
GO:0005739 mitochondrion C
IDA
SceS000000344
S000005441
GO:0005813 centrosome C
TAS
HsaP51955
GO:0016020 membrane C
IMP
SceS000000344
IPI
SceS000000344
GO:0004674 protein serine/threonine kinase
activity
F
TAS
HsaP51955
GO:0004857 enzyme inhibitor activity F
TAS
HsaP21359
GO:0005099 Ras GTPase activator activity F
IDA
SceS000005441
NR
HsaP21359
TAS
SceS000000344
GO:0005515 protein binding F
IPI
HsaP51955
GO:0007088 regulation of mitosis P
TAS
HsaP51955
GO:0007265 Ras protein signal transduction P
IMP
SceS000005441
S000000344
NR
HsaP21359
GO:0008285 negative regulation of cell proliferation P
TAS
HsaP21359
GO:0030437 sporulation (sensu Fungi) P
IMP
SceS000000344

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Inparanoid results:

Selected databases only

Inparanoid query cluster Phylogenetic pattern
S000005441

Species Link to cluster Score Model organism
protein page
UniProt link
Saccharomyces cerevisiae (Sce) query - S000005441
(YOL081W)
Anopheles gambiae (Aga) 717 1 ENSANGP00000003216
Saccharomyces cerevisiae (Sce) 717 0.412 S000000344
(YBR140C)
Saccharomyces cerevisiae (Sce) 1197 0.426 S000000344
(YBR140C)
Danio rerio (Dre) 696 1 ENSDARP00000004724
Danio rerio (Dre) 696 1 ENSDARP00000038158
Saccharomyces cerevisiae (Sce) 696 1 S000000344
(YBR140C)
Danio rerio (Dre) 696 0.82 ENSDARP00000043039
Takifugu rubripes (Fru) 724 1 SINFRUP00000145652
Saccharomyces cerevisiae (Sce) 724 0.41 S000000344
(YBR140C)
Gallus gallus (Gga) 1620 1 ENSGALP00000009067
(NF1)
P35608
Mus musculus (EMM) 775 1 ENSMUSP00000071289
(MGI:97306)
Q04690-1
Saccharomyces cerevisiae (Sce) 775 0.411 S000000344
(YBR140C)
Pan troglodytes (Ptr) 1353 1 ENSPTRP00000015309
Saccharomyces cerevisiae (Sce) 1353 1 S000000344
(YBR140C)
Rattus norvegicus (ERN) 708 1 ENSRNOP00000018448
Saccharomyces cerevisiae (Sce) 708 1 S000000344
(YBR140C)
Saccharomyces cerevisiae (Sce) 1270 1 S000000344
(YBR140C)
Mus musculus (Mmu) 757 1 MGI:97306 Q04690
Saccharomyces cerevisiae (Sce) 757 0.411 S000000344
(YBR140C)


GO terms for Inparanoid results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005441
GO:0005739 mitochondrion C
IDA
SceS000000344
S000005441
GO:0016020 membrane C
IMP
SceS000000344
IPI
SceS000000344
GO:0005099 Ras GTPase activator activity F
IDA
SceS000005441
TAS
SceS000000344
GO:0007265 Ras protein signal transduction P
IMP
SceS000005441
S000000344
GO:0030437 sporulation (sensu Fungi) P
IMP
SceS000000344
GO:0045685 regulation of glial cell differentiation P
IMP
MmuMGI:97306

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
49034

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) IRA2
(S000005441)
GI:6324491 P19158
Kluyveromyces lactis (Kla) KLLA0E17963g GI:50309497 Q6CMT2
Eremothecium gossypii (Ego) AER025C GI:45190631


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005441
GO:0005739 mitochondrion C
IDA
SceS000005441
GO:0005099 Ras GTPase activator activity F
IDA
SceS000005441
GO:0007265 Ras protein signal transduction P
IMP
SceS000005441

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_799

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga5427 ENSANGP00000003216
Anopheles gambiae (Aga) aga5426 ENSANGP00000025084
Ashbya gossypii (Ago) ago2530 AER025C
Candida glabrata (Cgl) cgl2864 CAGL0I07909g
Candida glabrata (Cgl) cgl5093 CAGL0M09999g
Cryptococcus neoformans (Cne) cne1156 180.m00084
Dictyostelium discoideum (Ddi) ddi5458 DDB0185273
Dictyostelium discoideum (Ddi) ddi8351 DDB0185880
Dictyostelium discoideum (Ddi) ddi1223 DDB0203607
Dictyostelium discoideum (Ddi) ddi5367 DDB0205121
Debaryomyces hansenii (Dha) dha6164 DEHA0G10494g
Drosophila melanogaster (Dme) dme14539 CG8318-PB
(FBgn0015269)
Drosophila melanogaster (Dme) dme14538 CG8318-PC
(FBgn0015269)
Danio rerio (Dre) dre2163 ENSDARP00000004724
Danio rerio (Dre) dre2165 ENSDARP00000006480
Danio rerio (Dre) dre2168 ENSDARP00000014824
Danio rerio (Dre) dre2167 ENSDARP00000040246
Danio rerio (Dre) dre6546 ENSDARP00000040420
Danio rerio (Dre) dre6543 ENSDARP00000041919
Danio rerio (Dre) dre6542 ENSDARP00000043039
Danio rerio (Dre) dre6545 ENSDARP00000044572
Danio rerio (Dre) dre2164 ENSDARP00000044691
Danio rerio (Dre) dre6541 ENSDARP00000045715
Danio rerio (Dre) dre6544 ENSDARP00000047244
Danio rerio (Dre) dre2166 ENSDARP00000049268
Takifugu rubripes (Fru) fru32722 SINFRUP00000145652
Gallus gallus (Gga) gga9088 ENSGALP00000008950
Gallus gallus (Gga) gga9096 ENSGALP00000009067
(NF1)
P35608
Gallus gallus (Gga) gga9097 ENSGALP00000009072
Homo sapiens (Hsa) hsa13404 ENSP00000348498
(NF1)
P21359-2
Homo sapiens (Hsa) hsa13403 ENSP00000351015
(NF1)
P21359-1
Homo sapiens (Hsa) hsa13405 ENSP00000352435
Kluyveromyces lactis (Kla) kla3756 KLLA0E17963g
Mus musculus (Mmu) mmu4351 ENSMUSP00000071289
(MGI:97306)
Q04690-1
Mus musculus (Mmu) mmu4354 ENSMUSP00000077722
Mus musculus (Mmu) mmu4353 ENSMUSP00000079018
Mus musculus (Mmu) mmu4352 ENSMUSP00000079110
Neurospora crassa (Ncr) ncr1596 NCU01642.2
Rattus norvegicus (Rno) rno5649 ENSRNOP00000018480
(RGD:3168)
Rattus norvegicus (Rno) rno5650 ENSRNOP00000045437
(RGD:3168)
Rattus norvegicus (Rno) rno5647 ENSRNOP00000049106
(RGD:3168)
Rattus norvegicus (Rno) rno5648 ENSRNOP00000050393
(RGD:3168)
P97526
Saccharomyces cerevisiae (Sce) sce405 YBR140C
(S000000344)
Saccharomyces cerevisiae (Sce) sce5633 YOL081W
(S000005441)
Yarrowia lipolytica (Yli) yli1043 YALI0B07535g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000005441
ISS
RnoRGD:3168
TAS
HsaP21359
GO:0005739 mitochondrion C
IDA
SceS000000344
S000005441
GO:0016020 membrane C
IMP
SceS000000344
IPI
SceS000000344
GO:0004857 enzyme inhibitor activity F
ISS
RnoRGD:3168
TAS
HsaP21359
GO:0005099 Ras GTPase activator activity F
IDA
SceS000005441
ISS
DmeFBgn0015269
RnoRGD:3168
NR
HsaP21359
TAS
DmeFBgn0015269
SceS000000344
GO:0007265 Ras protein signal transduction P
IMP
SceS000005441
S000000344
ISS
RnoRGD:3168
NR
HsaP21359
GO:0007611 learning and/or memory P
NAS
DmeFBgn0015269
GO:0007612 learning P
TAS
DmeFBgn0015269
GO:0007614 short-term memory P
TAS
DmeFBgn0015269
GO:0007622 rhythmic behavior P
NAS
DmeFBgn0015269
GO:0008285 negative regulation of cell proliferation P
ISS
RnoRGD:3168
TAS
HsaP21359
GO:0008355 olfactory learning P
TAS
DmeFBgn0015269
GO:0016049 cell growth P
NAS
DmeFBgn0015269
GO:0019933 cAMP-mediated signaling P
IMP
DmeFBgn0015269
NAS
DmeFBgn0015269
TAS
DmeFBgn0015269
GO:0030437 sporulation (sensu Fungi) P
IMP
SceS000000344
GO:0040014 regulation of body size P
TAS
DmeFBgn0015269
GO:0045475 locomotor rhythm P
NAS
DmeFBgn0015269
TAS
DmeFBgn0015269
GO:0045685 regulation of glial cell differentiation P
IMP
MmuMGI:97306
ISS
RnoRGD:3168
GO:0045762 positive regulation of adenylate cyclase
activity
P
IMP
DmeFBgn0015269

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GO info in one table:

s.khadayate@ucl.ac.uk