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Search term: YMR296C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LCB1
SGD link S000004911
Alternative ID YMR296C
Description Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
Synonyms YMR296C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1358 ACDHYPE

KOGs classification KOGs description
O
CELLULAR PROCESSES AND SIGNALING
Posttranslational modification, protein turnover, chaperones
Serine palmitoyltransferase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g36480 GI:4006914
Caenorhabditis elegans (Cel) CE08323
(WBGene00016020)
GI:17532023
Drosophila melanogaster (Dme) 7303358 GI:7303358 Q6NR46
Homo sapiens (Hsa) Hs5454084
(SPTLC1)
GI:5454084 O15269
Homo sapiens (Hsa) Hs17449618 GI:17449618
Saccharomyces cerevisiae (Sce) YMR296c
(S000004911)
GI:6323954 P25045
Schizosaccharomyces pombe (Spo) SPBC18E5.02c GI:19112640 O59682
Encephalitozoon cuniculi (Ecu) ECU02g0860 GI:19074005 Q8SSF4


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004911
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC18E5.02c
GO:0005792 microsome C
IPI
SceS000004911
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000004911
ISS
SpoSPBC18E5.02c
GO:0004758 serine C-palmitoyltransferase activity F
IDA
SceS000004911
ISS
SpoSPBC18E5.02c
RCA
AthAt4g36480
TAS
HsaO15269
GO:0006665 sphingolipid metabolism P
TAS
HsaO15269
GO:0007582 physiological process P
IMP
CelWBGene00016020
GO:0007626 locomotory behavior P
IMP
CelWBGene00016020
GO:0009792 embryonic development (sensu Metazoa) P
IMP
CelWBGene00016020
GO:0030148 sphingolipid biosynthesis P
ISS
SpoSPBC18E5.02c
RCA
AthAt4g36480
TAS
SceS000004911
GO:0040007 growth P
IMP
CelWBGene00016020
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00016020

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Inparanoid results:

Selected databases only

Inparanoid query cluster Phylogenetic pattern
S000004911

Species Link to cluster Score Model organism
protein page
UniProt link
Saccharomyces cerevisiae (Sce) query - S000004911
(YMR296C)
Anopheles gambiae (Aga) 714 1 ENSANGP00000010119
Canis familiaris (Cfa) 672 1 ENSCAFP00000003156
Danio rerio (Dre) 552 1 ENSDARP00000044059
Takifugu rubripes (Fru) 635 1 SINFRUP00000131714
Gallus gallus (Gga) 524 1 ENSGALP00000021940
(LOC426145)
Homo sapiens (Hsa) 700 1 ENSP00000262554
(SPTLC1)
O15269
Mus musculus (EMM) 654 1 ENSMUSP00000021920
(MGI:1099431)
Q3TTW4
Pan troglodytes (Ptr) 804 1 ENSPTRP00000036067
Rattus norvegicus (ERN) 644 1 ENSRNOP00000014546
(RGD:1307140)
Caenorhabditis elegans (Cel) 505 1 WBGene00016020
(CE08323)
Dictyostelium discoideum (Ddi) 547 1 DDB0189743
Drosophila melanogaster (Dme) 658 1 CG4016-PA
(FBgn0033800)
Mus musculus (Mmu) 634 1 MGI:1099431 O35704
Oryza sativa (Osa) 534 1 Q8L4Z0 Q8L4Z0
Oryza sativa (Osa) 534 0.94 Q6K8E7 Q6K8E7
Oryza sativa (Osa) 534 0.846 Q948H0 Q948H0
Schizosaccharomyces pombe (Spo) 1086 1 SPBC18E5.02c O59682
Arabidopsis thaliana (Ath) 661 1 NP_568005
(At4g36480.1)


GO terms for Inparanoid results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004911
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC18E5.02c
GO:0005792 microsome C
IPI
SceS000004911
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000004911
ISS
DmeFBgn0033800
SpoSPBC18E5.02c
GO:0004758 serine C-palmitoyltransferase activity F
IDA
SceS000004911
ISS
DmeFBgn0033800
RnoRGD:1307140
SpoSPBC18E5.02c
RCA
AthAt4g36480
TAS
HsaO15269
GO:0006665 sphingolipid metabolism P
ISS
RnoRGD:1307140
TAS
HsaO15269
GO:0007582 physiological process P
IMP
CelWBGene00016020
GO:0007626 locomotory behavior P
IMP
CelWBGene00016020
GO:0009792 embryonic development (sensu Metazoa) P
IMP
CelWBGene00016020
GO:0030148 sphingolipid biosynthesis P
ISS
SpoSPBC18E5.02c
RCA
AthAt4g36480
TAS
SceS000004911
GO:0040007 growth P
IMP
CelWBGene00016020
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00016020

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4681

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SPTLC1 GI:5454084 O15269
Canis familiaris (Cfa) LOC484192 GI:73946708
Mus musculus (Mmu) Sptlc1
(MGI:1099431)
GI:29244577 O35704
Rattus norvegicus (Rno) Sptlc1_predicted
(RGD:1307140)
GI:109504676
Gallus gallus (Gga) LOC426145 GI:50795880
Drosophila melanogaster (Dme) Spt-I
(FBgn0033800)
GI:24653276 Q6NR46
Anopheles gambiae (Aga) ENSANGG00000007630 GI:58381878 Q7QDU8
Caenorhabditis elegans (Cel) sptl-1
(CE08323;
WBGene00016020)
GI:71982617 P91079
Schizosaccharomyces pombe (Spo) SPBC29A3.20c GI:19112640
Saccharomyces cerevisiae (Sce) LCB1
(S000004911)
GI:6323954 P25045
Kluyveromyces lactis (Kla) KLLA0A09955g GI:50302995 Q6CXA4
Eremothecium gossypii (Ego) ABR145C GI:45185375
Magnaporthe grisea (Mgr) MG00864.4 GI:39973979
Neurospora crassa (Ncr) GeneID:2709055 GI:32413352
Arabidopsis thaliana (Ath) ATLCB1 GI:79326362 Q94IB8
Oryza sativa (Osa) OJ1111_C07.25 GI:50915674


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004911
GO:0005792 microsome C
IPI
SceS000004911
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000004911
ISS
DmeFBgn0033800
GO:0004758 serine C-palmitoyltransferase activity F
IDA
SceS000004911
ISS
DmeFBgn0033800
RnoRGD:1307140
TAS
HsaO15269
GO:0006665 sphingolipid metabolism P
ISS
RnoRGD:1307140
TAS
HsaO15269
GO:0007582 physiological process P
IMP
CelWBGene00016020
GO:0007626 locomotory behavior P
IMP
CelWBGene00016020
GO:0009792 embryonic development (sensu Metazoa) P
IMP
CelWBGene00016020
GO:0030148 sphingolipid biosynthesis P
TAS
SceS000004911
GO:0040007 growth P
IMP
CelWBGene00016020
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00016020

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2366

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga7329 ENSANGP00000010119
Ashbya gossypii (Ago) ago737 ABR145C
Arabidopsis thaliana (Ath) ath21815 At4g36480.1
Caenorhabditis elegans (Cel) cel2498 C23H3.4a
(CE08323;
WBGene00016020)
Caenorhabditis elegans (Cel) cel2499 C23H3.4b
(CE37749)
Candida glabrata (Cgl) cgl1645 CAGL0G00440g
Cryptococcus neoformans (Cne) cne2428 181.m08463
Dictyostelium discoideum (Ddi) ddi759 DDB0189743
Debaryomyces hansenii (Dha) dha3366 DEHA0E02783g
Drosophila melanogaster (Dme) dme4843 CG4016-PA
(FBgn0033800)
Drosophila melanogaster (Dme) dme4841 CG4016-PB
(FBgn0033800)
Drosophila melanogaster (Dme) dme4842 CG4016-PC
(FBgn0033800)
Danio rerio (Dre) dre17824 ENSDARP00000044059
Encephalitozoon cuniculi (Ecu) ecu84 19074005
Takifugu rubripes (Fru) fru6751 SINFRUP00000131714
Takifugu rubripes (Fru) fru6752 SINFRUP00000172191
Gallus gallus (Gga) gga26588 ENSGALP00000021940
(LOC426145)
Homo sapiens (Hsa) hsa31519 ENSP00000262554
(SPTLC1)
O15269
Kluyveromyces lactis (Kla) kla432 KLLA0A09955g
Mus musculus (Mmu) mmu6973 ENSMUSP00000021920
(MGI:1099431)
Q3TTW4
Neurospora crassa (Ncr) ncr6684 NCU06870.2
Oryza sativa (Osa) osa7561 2523.m00101
Oryza sativa (Osa) osa19020 3351.m00122
Oryza sativa (Osa) osa35997 4833.m00135
Oryza sativa (Osa) osa42530 5195.m00118
Oryza sativa (Osa) osa70495 7143.m00140
Rattus norvegicus (Rno) rno13064 ENSRNOP00000014546
(RGD:1307140)
Saccharomyces cerevisiae (Sce) sce5072 YMR296C
(S000004911)
Schizosaccharomyces pombe (Spo) spo1575 SPBC18E5.02c O59682
Yarrowia lipolytica (Yli) yli1847 YALI0C03179g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004911
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC18E5.02c
GO:0005792 microsome C
IPI
SceS000004911
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000004911
ISS
DmeFBgn0033800
SpoSPBC18E5.02c
GO:0004758 serine C-palmitoyltransferase activity F
IDA
SceS000004911
ISS
DmeFBgn0033800
RnoRGD:1307140
SpoSPBC18E5.02c
RCA
AthAt4g36480
TAS
HsaO15269
GO:0006665 sphingolipid metabolism P
ISS
RnoRGD:1307140
TAS
HsaO15269
GO:0007582 physiological process P
IMP
CelWBGene00016020
GO:0007626 locomotory behavior P
IMP
CelWBGene00016020
GO:0009792 embryonic development (sensu Metazoa) P
IMP
CelWBGene00016020
GO:0030148 sphingolipid biosynthesis P
ISS
SpoSPBC18E5.02c
RCA
AthAt4g36480
TAS
SceS000004911
GO:0040007 growth P
IMP
CelWBGene00016020
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00016020

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPBC18E5.02c
(O59682)
YMR296C
(S000004911)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004911
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC18E5.02c
GO:0005792 microsome C
IPI
SceS000004911
GO:0017059 serine C-palmitoyltransferase complex C
IMP
SceS000004911
ISS
SpoSPBC18E5.02c
GO:0004758 serine C-palmitoyltransferase activity F
IDA
SceS000004911
ISS
SpoSPBC18E5.02c
GO:0030148 sphingolipid biosynthesis P
ISS
SpoSPBC18E5.02c
TAS
SceS000004911

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Search for gene by ID or name:

Query species:

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GO info in one table:

s.khadayate@ucl.ac.uk