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Search term: YDL182W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LYS20
SGD link S000002341
Alternative ID YDL182W
Description Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
Synonyms YDL182W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2367 A---YP-

KOGs classification KOGs description
E
METABOLISM
Amino acid transport and metabolism
Alpha-isopropylmalate synthase/homocitrate synthase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g18500 GI:15221794
Arabidopsis thaliana (Ath) At1g74040 GI:15221125 Q9C550
Arabidopsis thaliana (Ath) At5g23010 GI:15237194 Q9FG67
Arabidopsis thaliana (Ath) At5g23020 GI:15237196 Q9FN52
Saccharomyces cerevisiae (Sce) YDL131w
(S000002289)
GI:6320071 Q12122
Saccharomyces cerevisiae (Sce) YDL182w
(S000002341)
GI:6320019 P48570
Saccharomyces cerevisiae (Sce) YNL104c
(S000005048)
GI:6324225 P06208
Saccharomyces cerevisiae (Sce) YOR108w
(S000005634)
GI:6324682 Q12166
Schizosaccharomyces pombe (Spo) SPBC1105.02c GI:19113250 Q9Y823
Schizosaccharomyces pombe (Spo) SPBC3E7.16c GI:19112895 O59736


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002289
S000002341
ISS
SpoSPBC1105.02c
GO:0005737 cytoplasm C
IDA
SceS000005048
ISS
SpoSPBC3E7.16c
RCA
SpoSPBC3E7.16c
GO:0005739 mitochondrion C
IDA
SceS000002341
S000005048
S000005634
SpoSPBC3E7.16c
ISS
SpoSPBC1105.02c
SPBC3E7.16c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0003852 2-isopropylmalate synthase activity F
IDA
SceS000005048
S000005634
IGI
AthAt1g74040
SceS000005634
ISS
AthAt1g74040
SceS000005634
SpoSPBC3E7.16c
NAS
AthAt5g23020
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002289
S000002341
GO:0009098 leucine biosynthesis P
IGI
AthAt1g74040
SceS000005634
IMP
SceS000005048
ISS
SpoSPBC3E7.16c
TAS
AthAt5g23020
GO:0019761 glucosinolate biosynthesis P
IGI
AthAt5g23020
IMP
AthAt5g23020
GO:0019878 lysine biosynthesis via aminoadipic
acid
P
IMP
SpoSPBC1105.02c
TAS
SceS000002341
S000002289

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Inparanoid results:

Selected databases only

Inparanoid query cluster Phylogenetic pattern
S000002341

Species Link to cluster Score Model organism
protein page
UniProt link
Saccharomyces cerevisiae (Sce) query - S000002341
(YDL182W)
Anopheles gambiae (Aga) 1940 1 ENSANGP00000011126
Saccharomyces cerevisiae (Sce) 1940 1 S000002289
(YDL131W)
Saccharomyces cerevisiae (Sce) 1725 0.894 S000002289
(YDL131W)
Canis familiaris (Cfa) 2045 1 ENSCAFP00000019305
Saccharomyces cerevisiae (Sce) 2045 1 S000002289
(YDL131W)
Canis familiaris (Cfa) 2045 0.638 ENSCAFP00000003388
Saccharomyces cerevisiae (Sce) 1885 0.894 S000002289
(YDL131W)
Danio rerio (Dre) 1791 1 ENSDARP00000004272
Saccharomyces cerevisiae (Sce) 1791 1 S000002289
(YDL131W)
Danio rerio (Dre) 1791 0.323 ENSDARP00000026028
(zgc:56248)
Q7ZV32
Saccharomyces cerevisiae (Sce) 2004 1 S000002289
(YDL131W)
Takifugu rubripes (Fru) 2004 1 SINFRUP00000136985
Takifugu rubripes (Fru) 2004 0.677 SINFRUP00000134746
Gallus gallus (Gga) 1859 1 ENSGALP00000026228
(HMGCLL1)
Saccharomyces cerevisiae (Sce) 1859 1 S000002289
(YDL131W)
Gallus gallus (Gga) 1859 0.66 ENSGALP00000006445
(HMGCL)
P35915
Homo sapiens (Hsa) 2135 1 ENSP00000274901
(HMGCLL1)
Q8TB92
Saccharomyces cerevisiae (Sce) 2135 1 S000002289
(YDL131W)
Homo sapiens (Hsa) 2135 0.628 ENSP00000235958
(HMGCL)
P35914
Mus musculus (EMM) 2110 1 ENSMUSP00000008052
(MGI:2446108)
Q8JZS7
Saccharomyces cerevisiae (Sce) 2110 1 S000002289
(YDL131W)
Mus musculus (EMM) 2110 0.618 ENSMUSP00000030432
(MGI:96158)
Q3UMP2
Saccharomyces cerevisiae (Sce) 1960 1 S000002289
(YDL131W)
Saccharomyces cerevisiae (Sce) 1707 0.894 S000002289
(YDL131W)
Caenorhabditis elegans (Cel) 1728 1 WBGene00022150
(CE26261)
Saccharomyces cerevisiae (Sce) 1728 0.894 S000002289
(YDL131W)
Dictyostelium discoideum (Ddi) 1963 1 DDB0230167
Saccharomyces cerevisiae (Sce) 1963 1 S000002289
(YDL131W)
Drosophila melanogaster (Dme) 1867 1 CG10399-PA
(FBgn0031877)
Saccharomyces cerevisiae (Sce) 1867 0.894 S000002289
(YDL131W)
Saccharomyces cerevisiae (Sce) 1704 0.894 S000002289
(YDL131W)
Mus musculus (Mmu) 2067 1 MGI:2446108 Q3TPS7
Saccharomyces cerevisiae (Sce) 2067 1 S000002289
(YDL131W)
Mus musculus (Mmu) 2067 0.61 MGI:96158 P38060
Saccharomyces cerevisiae (Sce) 257 1 S000002289
(YDL131W)
Schizosaccharomyces pombe (Spo) 257 1 SPBC1105.02c Q9Y823
Arabidopsis thaliana (Ath) 1107 1 NP_197693
(At5g23020.1)
Q9FN52
Saccharomyces cerevisiae (Sce) 1107 0.879 S000002289
(YDL131W)
Arabidopsis thaliana (Ath) 1107 0.743 NP_197692
(At5g23010.1)
Q9FG67
Arabidopsis thaliana (Ath) 1107 0.469 NP_173285
(At1g18500.1)
Arabidopsis thaliana (Ath) 1107 0.468 NP_177544
(At1g74040.1)
Q9C550
Escherichia coli (Eco) 259 1 NP_414616
(EG11226)
P09151
Saccharomyces cerevisiae (Sce) 259 1 S000002289
(YDL131W)


GO terms for Inparanoid results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005615 extracellular space C
RCA
MmuMGI:96158
GO:0005634 nucleus C
IDA
SceS000002289
S000002341
ISS
SpoSPBC1105.02c
GO:0005739 mitochondrion C
IDA
MmuMGI:96158
SceS000002341
ISS
SpoSPBC1105.02c
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:96158
GO:0005759 mitochondrial matrix C
ISS
DmeFBgn0031877
NAS
HsaP35914
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0003824 catalytic activity F
ISS
DdiDDB0230167
GO:0003852 2-isopropylmalate synthase activity F
IGI
AthAt1g74040
ISS
AthAt1g74040
NAS
AthAt5g23020
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002289
S000002341
GO:0004419 hydroxymethylglutaryl-CoA lyase
activity
F
ISS
DmeFBgn0031877
GO:0006091 generation of precursor metabolites and
energy
P
NR
HsaP35914
GO:0006520 amino acid metabolism P
ISS
DdiDDB0230167
NR
HsaP35914
GO:0006551 leucine metabolism P
ISS
DmeFBgn0031877
GO:0009098 leucine biosynthesis P
IGI
AthAt1g74040
TAS
AthAt5g23020
GO:0019761 glucosinolate biosynthesis P
IGI
AthAt5g23020
IMP
AthAt5g23020
GO:0019878 lysine biosynthesis via aminoadipic
acid
P
IMP
SpoSPBC1105.02c
TAS
SceS000002341
S000002289

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68618

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) LYS20
(S000002341)
GI:6320019 P48570
Kluyveromyces lactis (Kla) KLLA0E23782g GI:50310017 Q6CM17
Arabidopsis thaliana (Ath) MAM1 GI:15237194 Q9FG67


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002341
GO:0005739 mitochondrion C
IDA
SceS000002341
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
ISS
SceS000002341
GO:0019878 lysine biosynthesis via aminoadipic
acid
P
TAS
SceS000002341

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1575

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Ashbya gossypii (Ago) ago1848 ADR107W
Arabidopsis thaliana (Ath) ath1983 At1g18500.1
Arabidopsis thaliana (Ath) ath6710 At1g74040.1
Arabidopsis thaliana (Ath) ath24541 At5g23010.1
Arabidopsis thaliana (Ath) ath24542 At5g23020.1
Candida glabrata (Cgl) cgl3270 CAGL0J06402g
Candida glabrata (Cgl) cgl3396 CAGL0J09240g
Cryptococcus neoformans (Cne) cne764 163.m03889
Debaryomyces hansenii (Dha) dha2946 DEHA0D14498g
Debaryomyces hansenii (Dha) dha4801 DEHA0F09405g
Escherichia coli (Eco) eco75 16128068
(EG11226)
P09151
Kluyveromyces lactis (Kla) kla4021 KLLA0E23782g
Kluyveromyces lactis (Kla) kla4329 KLLA0F05489g
Neurospora crassa (Ncr) ncr5368 NCU05526.2
Oryza sativa (Osa) osa39150 4920.m00155
Oryza sativa (Osa) osa66663 6934.m00149
Oryza sativa (Osa) osa66676 6934.m00193
Oryza sativa (Osa) osa72588 7059.m00135
Saccharomyces cerevisiae (Sce) sce905 YDL131W
(S000002289)
Saccharomyces cerevisiae (Sce) sce960 YDL182W
(S000002341)
Schizosaccharomyces pombe (Spo) spo3662 SPBC1105.02c Q9Y823
Yarrowia lipolytica (Yli) yli6621 YALI0F31075g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002289
S000002341
ISS
SpoSPBC1105.02c
GO:0005739 mitochondrion C
IDA
SceS000002341
ISS
SpoSPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0003852 2-isopropylmalate synthase activity F
IGI
AthAt1g74040
ISS
AthAt1g74040
NAS
AthAt5g23020
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002289
S000002341
GO:0009098 leucine biosynthesis P
IGI
AthAt1g74040
TAS
AthAt5g23020
GO:0019761 glucosinolate biosynthesis P
IGI
AthAt5g23020
IMP
AthAt5g23020
GO:0019878 lysine biosynthesis via aminoadipic
acid
P
IMP
SpoSPBC1105.02c
TAS
SceS000002341
S000002289

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPBC1105.02c
(Q9Y823)
YDL182W
(S000002341)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000002341
ISS
SpoSPBC1105.02c
GO:0005739 mitochondrion C
IDA
SceS000002341
ISS
SpoSPBC1105.02c
GO:0005829 cytosol C
IDA
SpoSPBC1105.02c
GO:0004410 homocitrate synthase activity F
IEP
SceS000002341
IGI
SceS000002341
IMP
SceS000002341
SpoSPBC1105.02c
ISS
SceS000002341
GO:0019878 lysine biosynthesis via aminoadipic
acid
P
IMP
SpoSPBC1105.02c
TAS
SceS000002341

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

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